2023

Jacobs M, Olivero J, Choi HO, Liao CP, Kashemirov B, Katz J, Gross ME, McKenna CE. Synthesis and anti-cancer potential peripheral MAOA inhibitors designed to limit blood: brain penetration. Bioorg. Biomed. Chem. 2023; 117425(92), https://doi.org/10.1016/j.bmc.2023.117425.

Ren Y, Weeks J, Xue T, Rainbolt J, de Mesy Bentley KL, Shu Y, Liu Y, Masters E, Cherian P, McKenna CE, Neighbors J, Ebetino FH, Schwarz EM, Sun S, Xie C. Evidence of Bisphosphonate-Conjugated Sitafloxacin Eradication of Established Methicillin-Resistant S. aureus Infection with Osseointegration in Murine Models of Implant-Associated Osteomyelitis, Bone Res., preprint, https://doi.org/10.21203/rs.3.rs-2856287/v1 (in press 8/21/23)

Sodagar E, Sedghizadeh PP, Lacrampe RP, Bakhshalian N, Sun S, Cherian P, Garabedian R, Scholten S, Chen C, Junka AF, Neighbors JD, McKenna CE, Russel GG, Ebetino FH. Design, synthesis and in vivo testing of novel bisphosphonate-fluoroquinolone conjugates as bone graft substitutes for dental applications. J. Biomed. Mater. Res. (under revision, 8/2023).

Kremen TJ, Shi BY, Wu SY, Sundberg O, Kim W, Sriram V, Sheyn D, Lyons KM, Wang W, McKenna CE, Nishimura I. Biologically-Coupled Bisphosphonate Chaperones Effectively Deliver Molecules to the Site of Soft Tissue-Bone Healing. J Orthopaed Med. 2023; 41: 2250-2260. doi:10.1002/jor.25579

Mustafa D, Overhulse JM, Kashemirov BA, McKenna CE. Microwave-accelerated McKenna synthesis of phosphonic acids: an investigation. Molecules 2023, 28: 3497. https://doi.org/10.3390/molecules28083497

Kaiyao W, Justin MO, Marie A, Yingsheng Z, Dupper NJ, Kashemirov BA, Garnaud C, Bourgine G, Cornet M, Rabut G, McKenna CE, Petosa C, Govin J. Targeting fungal BET bromodomains as a pan-Candida antifungal strategy. bioRxiv. 2023:2023.02.03.527073. doi: 10.1101/2023.02.03.527073.

Sedghizadeh PP, Cherian P, Roshandel S, Tjokro N, Chen C, Junka AF, Hu E, Neighbors J, Pawlak J, Russell RGG, McKenna CE, Ebetino FH, Sun S, Sodagar E. Real-Time Impedance-Based Monitoring of the Growth and Inhibition of Osteomyelitis Biofilm Pathogen Staphylococcus aureus Treated with Novel Bisphosphonate-Fluoroquinolone Antimicrobial Conjugates. Int J Mol Sci. 2023;24(3). Epub 20230119. doi: 10.3390/ijms24031985. PubMed PMID: 36768310; PMCID: PMC9915994.

2022

Zhou Y, Overhulse JM, Dupper NJ, Guo Y, Kashemirov BA, Wei K, Govin J, Petosa C, McKenna CE. Toward more potent imidazopyridine inhibitors of Candida albicans Bdf1: Modeling the role of structural waters in selective ligand binding. J Comput Chem. 2022;43(32):2121-30. Epub 20221003. doi: 10.1002/jcc.26997. PubMed PMID: 36190786; PMCID: PMC9669269.

Kondo T, Okawa H, Hokugo A, Shokeen B, Sundberg O, Zheng Y, McKenna CE, Lux R, Nishimura I. Oral microbial extracellular DNA initiates periodontitis through gingival degradation by fibroblast-derived cathepsin K in mice. Commun Biol. 2022. 5(1):962. Epub 2022/09/15. doi: 10.1038/s42003-022-03896-7.

Okawa H, Kondo T, Hokugo A, Cherian P, Sundberg O, Campagna JJ, Kashemirov BA, John V, Sun S, Ebetino FH, McKenna CE, Nishimura I. Fluorescent risedronate analogue 800CW-pRIS improves tooth extraction-associated abnormal wound healing in zoledronate-treated mice. Commun Med (Lond). 2022. 2:112. Epub 2022/09/10. doi: 10.1038/s43856-022-00172-x.

Okawa H, Kondo T, Hokugo A, Cherian P, Campagna JJ, Lentini NA, Sung EC, Chiang S, Lin YL, Ebetino FH, John V, Sun S, McKenna CE, Nishimura I. Mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) revealed by targeted removal of legacy bisphosphonate from jawbone using equilibrium competing inert hydroxymethylene diphosphonate. Elife. 2022. 11. Epub 2022/08/27. doi: 10.7554/eLife.76207.

Lloyd MG, Liu D, Lyu J, Fan J, Overhulse JM, Kashemirov BA, Prichard MN, McKenna CE, Moffat JF. An acyclic phosphonate prodrug of HPMPC is effective against VZV in skin organ culture and mice. Antiviral Res. 2022. 199:105275. Epub 2022/03/07. doi: 10.1016/j.antiviral.2022.105275.

Lloyd M, Liu D, Lyu J, Fan J, Overhulse JM, Kashemirov BA, Prichard MN, McKenna CE, Moffat JF. An Acyclic Phosphonate Prodrug of HPMPC is Effective Against VZV in Skin Organ Culture and Mice -- BioRxiv (2022) doi: https://doi.org/10.1101/2022.01.30.478368.

2021

Sun S, Tao J, Sedghizadeh PP, Cherian P, Junka AF, Sodagar E, Xing L, Boeckman RK, Jr., Srinivasan V, Yao Z, Boyce BF, Lipe B, Neighbors JD, Russell RGG, McKenna CE, Ebetino FH. Bisphosphonates for delivering drugs to bone. Br J Pharmacol. 2021. 178(9):2008-2025. Epub 2020/09/03. doi: 10.1111/bph.15251.

Zheng Y, Haratipour P, Kashemirov BA, McKenna CE. Synthesis of 8-oxo-dGTP and its beta,gamma-CH2-, beta, gamma-CHF-, and beta, gamma-CF2- analogues. Tetrahedron Lett. 2021. 67. Epub 2021/03/16. doi: 10.1016/j.tetlet.2021.152890.

Ebetino FH, Sun S, Cherian P, Roshandel S, Neighbors JD, Hu E, Dunford JE, Sedghizadeh PP, McKenna CE, Srinivasan V, Boeckman RK, Russell RGG. Bisphosphonates: The role of chemistry in understanding their biological actions and structure-activity relationships, and new directions for their therapeutic use. Bone. 2022. 156:116289. Epub 2021/12/14. doi: 10.1016/j.bone.2021.116289.

Richard ET, Morinaga K, Zheng Y, Sundberg O, Hokugo A, Hui K, Zhou Y, Sasaki H, Kashemirov BA, Nishimura I, McKenna CE. Design and Synthesis of Cathepsin-K-Activated Osteoadsorptive Fluorogenic Sentinel (OFS) Probes for Detecting Early Osteoclastic Bone Resorption in a Multiple Myeloma Mouse Model. Bioconjug Chem. 2021. Epub 2021/05/07. doi: 10.1021/acs.bioconjchem.1c00036.

Pedowitz NJ, Jackson EG, Overhulse JM, McKenna CE, Kohler JJ, Pratt MR. Anomeric Fatty Acid Functionalization Prevents Nonenzymatic S-Glycosylation by Monosaccharide Metabolic Chemical Reporters. ACS Chem Biol. 2021. 16(10):1924-1929. Epub 2021/07/21. doi: 10.1021/acschembio.1c00470.

Patsch K, Liu C, Zapotoczny G, Sun Y, Sura H, Ung N, Sun RX, Haliday B, Yu C, Aljehani M, Lee JSH, Kashemirov BA, Agus DB, McKenna CE, Ruderman D. Paradoxical androgen receptor regulation by small molecule enantiomers. Proc Natl Acad Sci U S A. 2021. 118(12). Epub 2021/03/21. doi: 10.1073/pnas.2100918118.

Zheng Y, Haratipour P, Kashemirov BA, McKenna CE. Synthesis of 8-oxo-dGTP and its β,γ-CH2-, β,γ-CHF-, and β,γ-CF2- analogues. Tetrahedron Letters. 2021. 67:152890. doi: https://doi.org/10.1016/j.tetlet.2021.152890.

Kashemirov BA, Błażewska K, Justyna K, Lyu J, McKenna CE. 42.16.4 Phosphoric Acid and Derivatives. In: Jiang X, Marke I, Marschner C, et al., editors. Science of Synthesis Knowledge Updates. Stuttgart: Georg Thieme Verlag; 2021.

Sedghizadeh PP, Sun S, Jones AC, Sodagar E, Cherian P, Chen C, Junka AF, Neighbors JD, McKenna CE, Russell RGG, Ebetino FH. Bisphosphonates in dentistry: Historical perspectives, adverse effects, and novel applications. Bone. 2021. 147:115933. Epub 2021/03/25. doi: 10.1016/j.bone.2021.115933.

Setterholm NA, Haratipour P, Kashemirov BA, McKenna CE, Joyce GF. Kinetic Effects of beta,gamma-Modified Deoxynucleoside 5'-Triphosphate Analogues on RNA-Catalyzed Polymerization of DNA. Biochemistry. 2021. 60(1):1-5. Epub 2020/12/29. doi: 10.1021/acs.biochem.0c00779.

2020

Sun S, Tao J, Sedghizadeh PP, Cherian P, Junka AF, Sodagar E, Xing L, Boeckman RK, Jr., Srinivasan V, Yao Z, Boyce BF, Lipe B, Neighbors JD, Russell G, McKenna CE, Ebetino FH. Bisphosphonates for delivering drugs to bone. Br J Pharmacol. 2020. Epub 2020/09/03. doi: 10.1111/bph.15251. 

Seist R, Tong M, Landegger LD, Vasilijic S, Hyakusoku H, Katsumi S, McKenna CE, Edge ASB, Stankovic KM. Regeneration of Cochlear Synapses by Systemic Administration of a Bisphosphonate. Front Mol Neurosci. 2020. 13:87. Epub 2020/08/09. doi: 10.3389/fnmol.2020.00087.

McKenna CE, Haratipour P, Duro MVV, Ebetino FH. Chemistry of Bisphosphonates. In: Zaidi M, editor. Encyclopedia of Bone Biology. Oxford: Academic Press; 2020. p. 551-564

Haratipour P, Minard C, Nakhjiri M, Negahbani A, Chamberlain BT, Osuna J, Upton TG, Zhao M, Kashemirov BA, McKenna CE. Completing the beta,gamma-CXY-dNTP Stereochemical Probe Toolkit: Synthetic Access to the dCTP Diastereomers and (31)P and (19)F NMR Correlations with Absolute Configurations. J Org Chem. 2020. Epub 2020/10/31. doi: 10.1021/acs.joc.0c01204.

Batra VK, Alnajjar KS, Sweasy JB, McKenna CE, Goodman MF, Wilson SH. Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography. Biochemistry. 2020;59(8):955-963.

2019

Sun S, Hokugo A, Ebertino FH, Cherian P, McKenna CE, Nishimura I. P26 Competitive Equilibrium-based Bisphosphonate Displacement to enhance extraction socket healing in a model of the early stages of Bisphosphonate-related Osteonecrosis of the Jaw (BRONJ). Abstracts from the Bisphosphonates 50th anniversary meeting, July 15–17, 2019. JBMR Plus. 2019;3(S3):S67.

Sun S, Cherian P, Li Z, McKenna CE, Ebertino FH. P25 Bisphosphonate based imaging probes: new tools for bone imaging and disease diagnosis. Abstracts from the Bisphosphonates 50th anniversary meeting, July 15–17, 2019. JBMR Plus. 2019;3(S3):S66-S67.

Sedghizadeh P, Sun S, Cherian P, Sodagar E, Neighbors J, Russell RGG, McKenna CE, Ebetino FH. P21 Bone targeted fluoroquinolone antibiotic conjugate bisphosphonates for the treatment of osteomyelitis biofilms. Abstracts from the Bisphosphonates 50th anniversary meeting, July 15–17, 2019. JBMR Plus. 2019;3(S3):S64-S65.

McKenna CE. Bisphosphonates Redux: Designing the Next Generation of Bisphosphonates for New Biological and Medical Applications. Abstracts from the Bisphosphonates 50th anniversary meeting, July 15–17, 2019. JBMR Plus. 2019;3(S3):S23.

Haratipour P, Minard C, Nakhjiri M, Negahbani A, Kashemirov BA, McKenna CE. New chirally modified bisphosphonates for synthesis of individual beta,gamma-CHX-deoxynucleotide diastereomers. Phosphorus, Sulfur, and Silicon and the Related Elements. 2019;194(4-6):329-330.

Duro MVV, Alnajjar KS, Sweasy JB, Kashemirov BA, McKenna CE. Synthesis of ortho-Formylphenylphosphonic Acids as Covalent Probes of Active Site Lysines. Phosphorus Sulfur Silicon Relat Elem. 2019;194(4-6):313-314. 

Alnajjar KS, Krylov IS, Negahbani A, Haratipour P, Kashemirov BA, Huang J, Mahmoud M, McKenna CE, Goodman MF, Sweasy JB. A pre-catalytic non-covalent step governs DNA polymerase beta fidelity. Nucleic Acids Res. 2019;47(22):11839-11849.

Oertell K, Florian J, Haratipour P, Crans DC, Kashemirov BA, Wilson SH, McKenna CE, Goodman MF. A Transition-State Perspective on Y-Family DNA Polymerase eta Fidelity in Comparison with X-Family DNA Polymerases lambda and beta. Biochemistry. 2019;58(13):1764-73.

Hokugo A, Kanayama K, Sun S, Morinaga K, Sun Y, Wu Q, Sasaki H, Okawa H, Evans C, Ebetino FH, Lundy MW, Sadrerafi K, McKenna CE, Nishimura I. Rescue bisphosphonate treatment of alveolar bone improves extraction socket healing and reduces osteonecrosis in zoledronate-treated mice. Bone. 2019;123:115-28.

Duro MV, Mustafa D, McKenna CE. Phosphorus in chemical biology and medicinal chemistry. In: Iaroshenko V, editor. Organophosphorus Chemistry - From Molecules to Applications: Wiley‐VCH Verlag GmbH & Co. KGaA; 2019. p. 499-544.

Dupper NJ, Zhou Y, Govin J, McKenna CE. Chapter 11 - Bromodomain Inhibition and Its Application to Human Disease. In: Cacabelos R, editor. Pharmacoepigenetics: Academic Press; 2019. p. 475-92.

Chiminazzo A, Borsato G, Favero A, Fabbro C, McKenna CE, Dalle Carbonare LG, Valenti MT, Fabris F, Scarso A. Diketopyrrolopyrrole Bis-Phosphonate Conjugate: A New Fluorescent Probe for In Vitro Bone Imaging. Chemistry. 2019;25(14):3617-26.

2018

Toth K, Spencer JF, Ying B, Tollefson AE, Hartline CB, Richard ET, Fan J, Lyu J, Kashemirov BA, Harteg C, Reyna D, Lipka E, Prichard MN, McKenna CE and Wold WSM. USC-087 protects Syrian hamsters against lethal challenge with human species C adenoviruses. Antiviral Res. 2018;153:1-9. 

Oertell K, Kashemirov BA, Negahbani A, Minard C, Haratipour P, Alnajjar KS, Sweasy JB, Batra VK, Beard WA, Wilson SH, McKenna CE and Goodman MF. Probing DNA Base-Dependent Leaving Group Kinetic Effects on the DNA Polymerase Transition State. Biochemistry. 2018;57(26):3925-3933.

Kempfle JS, Nguyen K, Hamadani C, Koen N, Edge AS, Kashemirov BA, Jung DH and McKenna CE. Bisphosphonate-Linked TrkB Agonist: Cochlea-Targeted Delivery of a Neurotrophic Agent as a Strategy for the Treatment of Hearing Loss. Bioconjug Chem. 2018;29(4):1240-1250.

Elsayed R, Abraham P, Awad ME, Kurago Z, Baladhandayutham B, Whitford GM, Pashley DH, McKenna CE, Elsalanty ME. Removal of matrix-bound zoledronate prevents post-extraction osteonecrosis of the jaw by rescuing osteoclast function. Bone. 2018;110:141-9.

Batra VK, Oertell K, Beard WA, Kashemirov BA, McKenna CE, Goodman MF and Wilson SH. Mapping Functional Substrate-Enzyme Interactions in the pol beta Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs. Biochemistry. 2018;57(26):3934-3944.

2017

Sedghizadeh PP, Sun S, Junka AF, Richard E, Sadrerafi K, Mahabady S, Bakhshalian N, Tjokro N, Bartoszewicz M, Oleksy M, Szymczyk P, Lundy MW, Neighbors JD, Russell RG, McKenna CE, Ebetino FH. Design, Synthesis, and Antimicrobial Evaluation of a Novel Bone-Targeting Bisphosphonate-Ciprofloxacin Conjugate for the Treatment of Osteomyelitis Biofilms. J Med Chem. 2017;60:2326-2343.

Ni F, Kung A, Duan Y, Shah V, Amador CD, Guo M, Fan X, Chen L, Chen Y, McKenna CE, Zhang C. Remarkably Stereospecific Utilization of ATP alpha,beta-Halomethylene Analogues by Protein Kinases. J Am Chem Soc. 2017;139:7701-7704.

Nguyen K, Kempfle JS, Jung DH, McKenna CE. Recent advances in therapeutics and drug delivery for the treatment of inner ear diseases: a patent review (2011-2015). Expert Opin Ther Pat. 2017;27:191-202.

Mietton F, Ferri E, Champleboux M, Zala N, Maubon D, Zhou Y, Harbut M, Spittler D, Garnaud C, Courcon M, Chauvel M, d'Enfert C, Kashemirov BA, Hull M, Cornet M, McKenna CE, Govin J, Petosa C. Selective BET bromodomain inhibition as an antifungal therapeutic strategy. Nat Commun. 2017;8:15482.

Cohn Yakubovich D, Eliav U, Yalon E, Schary Y, Sheyn D, Cook-Wiens G, Sun S, McKenna CE, Lev S, Binshtok AM, Pelled G, Navon G, Gazit D, Gazit Z. Teriparatide attenuates scarring around murine cranial bone allograft via modulation of angiogenesis. Bone. 2017;97:192-200.

Alnajjar KS, Negahbani A, Nakhjiri M, Krylov IS, Kashemirov BA, McKenna CE, Goodman MF, Sweasy JB. DNA Polymerase beta Cancer-Associated Variant I260M Exhibits Nonspecific Selectivity toward the beta-gamma Bridging Group of the Incoming dNTP. Biochemistry. 2017;56:5449-5456.

Alnajjar KS, Garcia-Barboza B, Negahbani A, Nakhjiri M, Kashemirov B, McKenna C, Goodman MF, Sweasy JB. A Change in the Rate-Determining Step of Polymerization by the K289M DNA Polymerase beta Cancer-Associated Variant. Biochemistry. 2017;56:2096-2105.

2016

Sun S, Blazewska KM, Kadina AP, Kashemirov BA, Duan X, Triffitt JT, Dunford JE, Russell RG, Ebetino FH, Roelofs AJ, Coxon FP, Lundy MW, McKenna CE. Fluorescent Bisphosphonate and Carboxyphosphonate Probes: A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine. Bioconjug Chem. 2016;27:329-340.

Kang WS, Nguyen K, McKenna CE, Sewell WF, McKenna MJ, Jung DH. Measurement of Ototoxicity Following Intracochlear Bisphosphonate Delivery. Otol Neurotol. 2016;37:621-626.

Kang WS, Nguyen K, McKenna CE, Sewell WF, McKenna MJ, Jung DH. Intracochlear Drug Delivery Through the Oval Window in Fresh Cadaveric Human Temporal Bones. Otol Neurotol. 2016;37:218-222.

Jung DH, Kang WS, McKenna MJ, Sewell WF, Nguyen K, McKenna CE. Response to "Drug Diffusion to the Apex of the Human Cochlea?". Otol Neurotol. 2016;37:1463-1464.

Hwang CS, Xu L, Wang W, Ulrich S, Zhang L, Chong J, Shin JH, Huang X, Kool ET, McKenna CE, Wang D. Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitution. Nucleic Acids Res. 2016;44:3820-3828.

Ferri E, Petosa C, McKenna CE. Bromodomains: Structure, function and pharmacology of inhibition. Biochem Pharmacol. 2016;106:1-18.

2015

Verhulst A, Sun S, McKenna CE, D'Haese PC. Endocytotic uptake of zoledronic acid by tubular cells may explain its renal effects in cancer patients receiving high doses of the compound. PloS one. 2015;10:e0121861.

Tseng HC, Kanayama K, Kaur K, Park SH, Park S, Kozlowska A, Sun S, McKenna CE, Nishimura I, Jewett A. Bisphosphonate-induced differential modulation of immune cell function in gingiva and bone marrow in vivo: role in osteoclast-mediated NK cell activation. Oncotarget. 2015;6:20002-20025.

Kang WS, Sun S, Nguyen K, Kashemirov B, McKenna CE, Hacking SA, Quesnel AM, Sewell WF, McKenna MJ, Jung DH. Non-Ototoxic Local Delivery of Bisphosphonate to the Mammalian Cochlea. Otol Neurotol. 2015;36:953-960.

Kadina AP, Kashemirov BA, Oertell K, Batra VK, Wilson SH, Goodman MF, McKenna CE. Two Scaffolds from Two Flips: (alpha,beta)/(beta,gamma) CH2/NH "Met-Im" Analogues of dTTP. Organic letters. 2015;17:2586-2589.

Junankar S, Shay G, Jurczyluk J, Ali N, Down J, Pocock N, Parker A, Nguyen A, Sun S, Kashemirov B, McKenna CE, Croucher PI, Swarbrick A, Weilbaecher K, Phan TG, Rogers MJ. Real-time intravital imaging establishes tumor-associated macrophages as the extraskeletal target of bisphosphonate action in cancer. Cancer discovery. 2015;5:35-42.

Hwang CS, Kung A, Kashemirov BA, Zhang C, McKenna CE. 5'-beta,gamma-CHF-ATP diastereomers: synthesis and fluorine-mediated selective binding by c-Src protein kinase. Organic letters. 2015;17:1624-1627.

2014

Seamon KJ, Hansen EC, Kadina AP, Kashemirov BA, McKenna CE, Bumpus NN, Stivers JT. Small molecule inhibition of SAMHD1 dNTPase by tetramer destabilization. J Am Chem Soc. 2014;136:9822-9825.

Oertell K, Chamberlain BT, Wu Y, Ferri E, Kashemirov BA, Beard WA, Wilson SH, McKenna CE, Goodman MF. Transition state in DNA polymerase beta catalysis: rate-limiting chemistry altered by base-pair configuration. Biochemistry. 2014;53:1842-1848.

Hwang CS, Kashemirov BA, McKenna CE. On the observation of discrete fluorine NMR spectra for uridine 5'-beta,gamma-fluoromethylenetriphosphate diastereomers at basic pH. J Org Chem. 2014;79:5315-5319.

Cheong S, Sun S, Kang B, Bezouglaia O, Elashoff D, McKenna CE, Aghaloo TL, Tetradis S. Bisphosphonate uptake in areas of tooth extraction or periapical disease. J Oral Maxillofac Surg. 2014;72:2461-2468.

Bae S, Sun S, Aghaloo T, Oh JE, McKenna CE, Kang MK, Shin KH, Tetradis S, Park NH, Kim RH. Development of oral osteomucosal tissue constructs in vitro and localization of fluorescently-labeled bisphosphonates to hard and soft tissue. Int J Mol Med. 2014;34:559-563.

2013

Vermeer JA, Jansen ID, Marthi M, Coxon FP, McKenna CE, Sun S, de Vries TJ, Everts V. Jaw bone marrow-derived osteoclast precursors internalize more bisphosphonate than long-bone marrow precursors. Bone. 2013;57:242-251.

Ni F, Lee CC, Hwang CS, Hu YL, Ribbe MW, McKenna CE. Reduction of Fluorinated Cyclopropene by Nitrogenase. J Am Chem Soc. 2013;135:10346-10352.

Krylov IS, McKenna CE. Enzymatically Activated Phosphate and Phosphonate Prodrugs. In: Yang H-C, Yeh W-K, McCarthy JR, editors. Enzyme Technologies: Pluripotent Players in Discovering Therapeutic Agents. Hoboken, NJ: John Wiley & Sons, Inc; 2013. p. 253-300.

Krylov IS, Kashemirov BA, Hilfinger JM, McKenna CE. Evolution of an Amino Acid Based Prodrug Approach: Stay Tuned. Mol Pharm. 2013;10:445-458.

Hokugo A, Sun S, Park S, McKenna CE, Nishimura I. Equilibrium-dependent bisphosphonate interaction with crystalline bone mineral explains anti-resorptive pharmacokinetics and prevalence of osteonecrosis of the jaw in rats. Bone. 2013;53:59-68.

Emadali A, Rousseaux S, Bruder-Costa J, Rome C, Duley S, Hamaidia S, Betton P, Debernardi A, Leroux D, Bernay B, Kieffer-Jaquinod S, Combes F, Ferri E, McKenna CE, Petosa C, Bruley C, Garin J, Ferro M, Gressin R, Callanan MB, Khochbin S. Identification of a novel BET bromodomain inhibitor-sensitive, gene regulatory circuit that controls Rituximab response and tumour growth in aggressive lymphoid cancers. EMBO molecular medicine. 2013;5:1180-1195.

2012

Wu Y, Zakharova VM, Kashemirov BA, Goodman MF, Batra VK, Wilson SH, McKenna CE. beta,gamma-CHF- and beta,gamma-CHCl-dGTP diastereomers: synthesis, discrete 31P NMR signatures, and absolute configurations of new stereochemical probes for DNA polymerases. J Am Chem Soc. 2012;134:8734-8737.

Ward SE, Kim HS, Komurov K, Mendiratta S, Tsai PL, Schmolke M, Satterly N, Manicassamy B, Forst CV, Roth MG, Garcia-Sastre A, Blazewska KM, McKenna CE, Fontoura BM, White MA. Host modulators of H1N1 cytopathogenicity. PloS one. 2012;7:e39284.

Turek J, Ebetino FH, Lundy MW, Sun S, Kashemirov BA, McKenna CE, Gallant MA, Plotkin LI, Bellido T, Duan X, Triffitt JT, Russell RG, Burr DB, Allen MR. Bisphosphonate binding affinity affects drug distribution in both intracortical and trabecular bone of rabbits. Calcif Tissue Int. 2012;90:202-210.

Roelofs AJ, Stewart C, Sun S, Blazewska KM, Kashemirov BA, McKenna CE, Russell RGG, Rogers MJ, Lundy MW, Ebetino FH, Coxon FP. Influence of bone affinity on skeletal distribution of fluorescently-labeled bisphosphonate analogues. J Bone Miner Res. 2012;27:835-847.

Oertell K, Wu Y, Zakharova VM, Kashemirov BA, Shock DD, Beard WA, Wilson SH, McKenna CE, Goodman MF. Effect of beta,gamma-CHF- and beta,gamma-CHCl-dGTP halogen atom stereochemistry on the transition state of DNA polymerase beta. Biochemistry. 2012;51:8491-8501.

Lempinen M, Halme L, Arola J, Honkanen E, Salmela K, Lautenschlager I. HHV-6B is frequently found in the gastrointestinal tract in kidney transplantation patients. Transpl Int. 2012;25:776-782.

Krylov IS, Zakharova VM, Serpi M, Haiges R, Kashemirov BA, McKenna CE. Structure of Cyclic Nucleoside Phosphonate Ester Prodrugs: An Inquiry. J Org Chem. 2012;77:684-689.

Chamberlain BT, Batra VK, Beard WA, Kadina AP, Shock DD, Kashemirov BA, McKenna CE, Goodman MF, Wilson SH. Stereospecific formation of a ternary complex of (S)-alpha,beta-fluoromethylene-dATP with DNA pol beta. Chembiochem. 2012;13:528-530.

Batra VK, Shock DD, Beard WA, McKenna CE, Wilson SH. Binary complex crystal structure of DNA polymerase β reveals multiple conformations of the templating 8-oxoguanine lesion. Proc Natl Acad Sci U S A. 2012;109:113-118.

Arora DK, Syed I, Machhadieh B, McKenna CE, Kowluru A. Rab-geranylgeranyl transferase regulates glucose-stimulated insulin secretion from pancreatic beta cells. Islets. 2012;4:354-358.

2011

Zakharova VM, Serpi M, Krylov IS, Peterson LW, Breitenbach JM, Borysko KZ, Drach JC, Collins M, Hilfinger JM, Kashemirov BA, McKenna CE. Tyrosine-Based 1-(S)-[3-Hydroxy-2 (phosphonomethoxy)propyl]cytosine and -adenine ((S)-HPMPC and (S)-HPMPA) Prodrugs: Synthesis, Stability, Antiviral Activity, and in Vivo Transport Studies. J Med Chem. 2011;54:5680-5693.

Zakharova VM, Krylov IS, Serpi M, Kashemirov BA, McKenna CE. Approaches to Tyrosine-Linked Peptidomimetic Prodrugs of (S)-HPMP-Based Acyclic Nucleoside Phosphonates. Phosphorus Sulfur Silicon Relat Elem. 2011;186:968-969.

Williams MM, Krylov IS, Zakharova VM, Serpi M, Peterson LW, Krecmerova M, Kashemirov BA, McKenna CE. Cyclic and acyclic phosphonate tyrosine ester prodrugs of acyclic nucleoside phosphonates. In: Hocek M, editor. XVth Symposium on Chemistry of Nucleic Acid Components. Český Krumlov, Czech Republic: Institute of Organic Chemistry and Biochemistry Academy of Sciences of the Czech Republic; 2011. p. 167-170.

Sun S, McKenna CE. Farnesyl pyrophosphate synthase modulators: a patent review (2006 - 2010). Expert Opin Ther Pat. 2011;21:1433-1451.

Sun S, Blazewska KM, Kashemirov BA, Roelofs AJ, Coxon FP, Rogers MJ, Ebetino FH, McKenna MJ, McKenna CE. Synthesis and characterization of novel fluorescent nitrogen-containing bisphosphonate imaging probes for bone active drugs. Phosphorus Sulfur Silicon Relat Elem. 2011;186:970-971.

Peterson LW, Kim JS, Kijek P, Mitchell S, Hilfinger J, Breitenbach J, Borysko K, Drach JC, Kashemirov BA, McKenna CE. Synthesis, transport and antiviral activity of Ala-Ser and Val-Ser prodrugs of cidofovir. Bioorg Med Chem Lett. 2011;21:4045-4049.

Mustafa DA, Kashemirov BA, McKenna CE. Microwave-assisted synthesis of nitrogen-containing 1-hydroxymethylene bisphosphonate drugs. Tetrahedron Lett. 2011;52:2285-2287.

McKenna CE, Kashemirov BA, Zakharova VM, Krylov IS, Williams MM, Krecmerova M, Drach JC, Hilfinger JM. Amido tyrosine esters: a promising new approach to antiviral nucleoside phosphonate prodrugs. Antiviral Res. 2011;90:A23-A24.

Gaidamauskas E, Crans DC, Parker H, Saejueng K, Kashemirov BA, McKenna CE. Quantification of foscarnet with chromogenic and fluorogenic chemosensors: indicator displacement assays based on metal ion coordination with catechol ligand moiety. New J Chem. 2011;35:2877-2883.

Ebetino FH, Hogan AM, Sun S, Tsoumpra MK, Duan X, Triffitt JT, Kwaasi AA, Dunford JE, Barnett BL, Oppermann U, Lundy MW, Boyde A, Kashemirov BA, McKenna CE, Russell RGG. The relationship between the chemistry and biological activity of the bisphosphonates. Bone. 2011;49:20-33.

Chamberlain BT, Upton TG, Kashemirov BA, McKenna CE. α-Azido Bisphosphonates: Synthesis and Nucleotide Analogues. J Org Chem. 2011;76:5132-5136.

Chamberlain BT, Osuna J, Kashemirov BA, McKenna CE. Synthesis and Sensing of Bisphosphonophosphate Alkyl Monoesters: A Novel Class of Compounds for the Study of Nucleoside 5′-Triphosphate Chemistry. Phosphorus Sulfur Silicon Relat Elem. 2011;186:966-967.

Blazewska KM, Ni F, Haiges R, Kashemirov BA, Coxon FP, Stewart CA, Baron R, Rogers MJ, Seabra MC, Ebetino FH, McKenna CE. Synthesis, stereochemistry and SAR of a series of minodronate analogues as RGGT inhibitors. Eur J Med Chem. 2011;46:4820-4826.

Blazewska KM, Haiges R, Kashemirov BA, Ebetino FH, McKenna CE. A serendipitous phosphonocarboxylate complex of boron: when vessel becomes reagent. Chem Commun. 2011;47:6395-6397.

2010

Zhang H, Pang W, Marma MS, Lee CY, Kamal-Bahl S, Kim ES, McKenna CE. Label-free detection of protein-ligand interactions in real time using micromachined bulk acoustic resonators. Appl Phys Lett. 2010;96:123702.

Tian X, Jin RU, Bredemeyer AJ, Oates EJ, Blazewska KM, McKenna CE, Mills JC. RAB26 and RAB3D Are Direct Transcriptional Targets of MIST1 That Regulate Exocrine Granule Maturation. Mol Cell Biol. 2010;30:1269-1284.

Tehler U, Nelson CH, Peterson LW, Provoda CJ, Hilfinger JM, Lee KD, McKenna CE, Amidona GL. Puromycin-sensitive aminopeptidase: An antiviral prodrug activating enzyme. Antiviral Res. 2010;85:482-489.

Serpi M, Krylov IS, Zakharova VM, McKenna CE. Synthesis of Peptidomimetic Conjugates of Cyclic Nucleoside Phosphonates. Curr Protoc Nucleic Acid Chem. 2010;Chapter 15:Unit15.4.

Roelofs AJ, Coxon FP, Ebetino FH, Lundy MW, Henneman ZJ, Nancollas GH, Sun S, Blazewska KM, Bala JL, Kashemirov BA, Khalid AB, McKenna CE, Rogers MJ. Fluorescent risedronate analogues reveal bisphosphonate uptake by bone marrow monocytes and localization around osteocytes in vivo. J Bone Miner Res. 2010;25:606-616.

Prakash GKS, Zibinsky M, Upton TG, Kashemirov BA, McKenna CE, Oertell K, Goodman MF, Batra VK, Pedersen LC, Beard WA, Shock DD, Wilson SH, Olah GA. Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid. Proc Natl Acad Sci U S A. 2010;107:15693-15698.

Peterson LW, Sala-Rabanal M, Krylov IS, Serpi M, Kashemirov BA, McKenna CE. Serine Side Chain-Linked Peptidomimetic Conjugates of Cyclic HPMPC and HPMPA: Synthesis and Interaction with hPEPT1. Molecular pharmaceutics. 2010;7:2349-2361.

Parker M, Brugeaud A, Edge ASB. Primary Culture and Plasmid Electroporation of the Murine Organ of Corti. 2010:e1685.

Pan JJ, Kashemirov BA, Lee J, McKenna CE, Devlin FJ, Stephens PJ. Electronic circular dichroism of monomethyl [16O,17O,18O]-phosphate and [16O,17O,18O]-thiophosphate revisited. Bioorg Chem. 2010;38:7-16.

McKenna CE, Kashemirov BA, Peterson LW, Goodman MF. Modifications to the dNTP triphosphate moiety: From mechanistic probes for DNA polymerases to antiviral and anti-cancer drug design. Biochim Biophys Acta. 2010;1804:1223-1230.

McKenna CE, Kashemirov BA, Blazewska KM, Mallard-Favier I, Stewart CA, Rojas J, Lundy MW, Ebetino FH, Baron RA, Dunford JE, Kirsten ML, Seabra MC, Bala JL, Marma MS, Rogers MJ, Coxon FP. Synthesis, Chiral High Performance Liquid Chromatographic Resolution and Enantiospecific Activity of a Potent New Geranylgeranyl Transferase Inhibitor, 2-Hydroxy-3-imidazo[1,2-a]pyridin- 3-yl-2-phosphonopropionic Acid. J Med Chem. 2010;53:3454-3464.

Fu K, Xu Q, Czernuszka J, McKenna CE, Ebetino FH, Russell RGG, Triffitt JT, Xia Z. Prolonged osteogenesis from human mesenchymal stem cells implanted in immunodeficient mice by using coralline hydroxyapatite incorporating rhBMP2 microspheres. J Biomed Mater Res A. 2010;92:1256-1264.

Cameron B, Flamand L, Juwana H, Middeldorp J, Naing Z, Rawlinson W, Ablashi D, Lloyd A. Serological and virological investigation of the role of the herpesviruses EBV, CMV and HHV-6 in post-infective fatigue syndrome. J Med Virol. 2010;82:1684-1688.

Batra VK, Pedersen LC, Beard WA, Wilson SH, Kashemirov BA, Upton TG, Goodman MF, McKenna CE. Halogenated β,γ-Methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase β: Structural Evidence for Stereospecific Binding of the Fluoromethylene Analogues. J Am Chem Soc. 2010;132:7617-7625.

Bala JLF, Kashemirov BA, McKenna CE. Synthesis of a Novel Bisphosphonic Acid Alkene Monomer. Synthetic Commun. 2010;40:3577-3584.

2009

Upton TG, Kashemirov BA, McKenna CE, Goodman MF, Prakash GK, Kultyshev R, Batra VK, Shock DD, Pedersen LC, Beard WA, Wilson SH. α,β-difluoromethylene deoxynucleoside 5'-triphosphates: a convenient synthesis of useful probes for DNA polymerase β structure and function. Organic letters. 2009;11:1883-1886.

Sala-Rabanal M, Peterson LW, Serpi M, Krylov IS, Kashemirov BA, Kim JS, Mitchell S, Hilfinger JM, McKenna CE. Interactions Between the Human Oligopeptide Transporter, hPepT1 and Serine Side-chain-linked Cidofovir Prodrugs. Antiviral Res. 2009;82:A53-A54.

Roelofs AJ, Boyde A, Lundy MW, McKenna CE, Blazewska K, Sun ST, Kashemirov BA, Russell RGG, Ebetino FH, Rogers MJ, Coxon FP. Bone mineral affinity influences the distribution of a bisphosphonate and a lower affinity analogue in vivo. Bone. 2009;44:S430-S431.

Peterson LW, McKenna CE. Prodrug approaches to improving the oral absorption of antiviral nucleotide analogues. Expert Opin Drug Deliv. 2009;6:405-420.

Metlushka KE, Kashemirov BA, Zheltukhin VF, Sadkova DN, Buchner B, Hess C, Kataeva ON, McKenna CE, Alfonsov VA. 1-(α-Aminobenzyl)-2-naphthol: A New Chiral Auxiliary for the Synthesis of Enantiopure α-Aminophosphonic Acids. Chemistry. 2009;15:6718-6722.

McKenna CE, Peterson LW, Kashemirov BA, Serpi M, Mitchell S, Kim JS, Hilfinger JM, Drach JC. New peptidomimetic prodrugs of acyclic and cyclic cidofovir: sar studies of chemical and enzymatic activation mechanisms. Antiviral Res. 2009;82:A75.

McKenna CE, Kashemirov BA, Blazewska KM. Product Class Phosphoric Acid [PO(OH)³] and Derivatives. Science of Synthesis, Houben-Weyl Methods of Molecular Transformations. Stuttgart: Georg Thieme Verlag; 2009. p. 779-921.

Krylov IS, Peterson LW, Kashemirov BA, Breitenbach J, Borysco K, Drach JC, Kim JS, Hilfinger JM, McKenna CE. In vitro transport, activation and antiviral evaluation of new HPMPA prodrugs synthesized on a solid support. Antiviral Res. 2009;82:A75.

Kamerlin SC, McKenna CE, Goodman MF, Warshel A. A Computational Study of the Hydrolysis of dGTP Analogues with Halomethylene-Modified Leaving Groups in Solution: Implications for the Mechanism of DNA Polymerases. Biochemistry. 2009;48:5963-5971.[1]

Gaidamauskas E, Parker H, Kashemirov BA, Holder AA, Saejueng K, McKenna CE, Crans DC. Complexation of bisphosphonates with ytterbium(III): Application of phosphate and ATP detection assay based on Yb3+-pyrocatechol violet. J Inorg Biochem. 2009;103:1652-1657.

Boyde A, Lundy MW, Coxon FP, McKenna CE, Roelofs A, Bala J, Rogers MJ, Blazewska K, Russell RGG, Ebetino FH. The differential distribution in vivo of fluorescently-labeled bisphosphonate analogues with different mineral affinity to bone surfaces. Bone. 2009;44:S57.

Baron RA, Tavare R, Figueiredo AC, Blazewska KM, Kashemirov BA, McKenna CE, Ebetino FH, Taylor A, Rogers MJ, Coxon FP, Seabra MC. Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranylgeranyl transferase. J Biol Chem. 2009;284:6861-6868.

2008

Tavare R, Baron R, Taylor A, Seabra MC, Blazewska KM, McKenna CE, Kashemirov BA, Ebetino FH, Rogers MJ, Coxon FP. Characterisation of the inhibition of rab prenylation by phosphonocarboxylates. Bone. 2008;42:S88-S89.

Sucato CA, Upton TG, Kashemirov BA, Osuna J, Oertell K, Beard WA, Wilson SH, Florian J, Warshel A, McKenna CE, Goodman MF. DNA Polymerase β Fidelity: Halomethylene-Modified Leaving Groups in Pre-Steady-State Kinetic Analysis Reveal Differences at the Chemical Transition State. Biochemistry. 2008;47:870-879.

Stewart CA, Baron R, Marma MS, Blazewska KM, Kashemirov BA, Ebetino FH, McKenna CE, Rogers MJ, Coxon FP. Structure activity relationships of phosphonocarboxylate inhibitors of rab geranylgeranyl transferase. Bone. 2008;42:S86-S87.

Stewart CA, Baron R, Blazewska KM, Kashemirov BA, Ebetino FH, Navea JR, McKenna CE, Rogers MJ, Coxon FP. Differential inhibition of rab geranylgeranyl transferase by stereoisomers of phosphonocarboxylates. Bone. 2008;42:S87.

Roelofs AJ, Coxon FP, Lundy MW, Ebetino FH, Bala JF, Kashemirov BA, McKenna CE, Rogers MJ. Studying Cellular Uptake and Distribution of Bisphosphonate in vivo Using Fluorescently-labelled Analogues of Risedronate. J Bone Miner Res. 2008;23:S20.

Roelofs AJ, Coxon FP, Ebetino FH, Bala JF, Kashemirov BA, McKenna CE, Rogers MJ. Visualisation of cellular uptake and localisation of bisphosphonate in vivo using a fluorescent analogue of risedronate. Calcif Tissue Int. 2008;82:S59.

Roelofs AJ, Coxon FP, Ebetino FH, Bala JF, Kashemirov BA, McKenna CE, Rogers MJ. Use of a fluorescent analogue of risedronate to study localisation and cellular uptake of bisphosphonates in vivo. Bone. 2008;42:S85.

Pham CV, Kashemirov BA, Osuna J, Saejueng K, Hilfinger JM, McKenna CE. Synthesis of P–O–C-linked Foscarnet–Peptide Conjugates and Sensitive Methods to Detect the Released Drug in Biological Samples. Antiviral Res. 2008;78:A62.

Peterson LW, Kashemirov BA, Eriksson U, Kim JS, Mitchell S, Kijek P, Lee KD, Hilfinger JM, McKenna CE. Serine Side-Chain-linked Peptidomimetic Prodrugs of Cidofovir and Cyclic Cidofovir: C-Ester Effects on Transport and Activation. Antiviral Res. 2008;78:A46.

Metlushka KE, Alfonsov VA, McKenna CE, Kashemirov BA, Kataeva ON, Zheltukhin VF, Sadkova DN, Dobrynin AB. Phosphonylation of 1,3-Diaryl-2,3-dihydro-1H-naphth[1,2-e][1,3]oxazine by Dialkyl and Diaryl Phosphonates. Phosphorus Sulfur Silicon Relat Elem. 2008;183:2645-2646.

Kotti T, Head DD, McKenna CE, Russell DW. Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation. Proc Natl Acad Sci U S A. 2008;105:11394-11399.

Kashemirov BA, Bala JL, Chen X, Ebetino FH, Xia Z, Russell RGG, Coxon FP, Roelofs AJ, Rogers MJ, McKenna CE. Fluorescently Labeled Risedronate and Related Analogues: “Magic Linker” Synthesis. Bioconjug Chem. 2008;19:2308-2310.

Gaidamauskas E, Saejueng K, Holder AA, Bharuah S, Kashemirov BA, Crans DC, McKenna CE. Metal complexation chemistry used for phosphate and nucleotide determination: an investigation of the Yb3+-pyrocatechol violet sensor. J Biol Inorg Chem. 2008;13:1291-1299.

Eriksson U, Peterson LW, Kashemirov BA, Hilfinger JM, Drach JC, Borysko KZ, Breitenbach JM, Kim JS, Mitchell S, Kijek P, McKenna CE. Serine Peptide Phosphoester Prodrugs of Cyclic Cidofovir: Synthesis, Transport, and Antiviral Activity. Molecular pharmaceutics. 2008;5:598-609.

Ebetino FH, Dunford JE, Lundy MW, Pozzi M, Xia Z, Dobson R, Quijano M, Christian R, Kashemirov BA, McKenna CE, Russell GG, Barnett BL. A mirror image pair of bisphosphonate analogs further demonstrates the mode of binding of the bisphosphonates in farnesyl pyrophosphate synthase. Bone. 2008;42:S36-S37.

Deprele S, Kashemirov BA, Hogan JM, Ebetino FH, Barnett BL, Evdokimov A, McKenna CE. Farnesyl pyrophosphate synthase enantiospecificity with a chiral risedronate analog, [6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl(hydroxy)methylene]bis(phosphonic acid) (NE-10501): Synthetic, structural, and modeling studies. Bioorg Med Chem Lett. 2008;18:2878-2882.

Coxon FP, Stewart CA, Tavare R, Baron R, Taylor A, Marma MS, Blazewska KM, Kashemirov BA, Ebetino FH, Seabra MC, Rogers MJ, McKenna CE. Inhibition of Rab geranylgeranyl transferase and Rab prenylation by phosphonocarboxylate drugs. Calcif Tissue Int. 2008;82:S127.

Coxon FP, Bala JL, Kashemirov BA, Lundy MW, Chen XL, Xia Z, Dunford JE, Russell GG, Roelofs AJ, Rogers MJ, McKenna CE, Ebetino FH. Fluorescently labeled risedronate and related analogs: Design and evaluation as imaging probes. Bone. 2008;42:S36.

Alfonsov VA, McKenna CE, Bayandina EV, Kashemirov BA, Yarmieva LN, Punegova LN, Kataeva ON. Stereoselective Synthesis of Enantiopure Cyclic α-Aminophosphonic Acids: Direct Observation of Inversion at Phosphorus in Phosphonate Ester Silyldealkylation by Bromotrimethylsilane. Heteroatom Chem. 2008;19:575-582.

Alfonsov VA, McKenna CE, Bayandina EV, Kashemirov B, Yarmieva LN, Kataeva ON, Punegova LN. Diastereoselective Synthesis of Enantiopure Cyclic α-Aminophosphonic Acids. Phosphorus Sulfur Silicon Relat Elem. 2008;183:2647-2648.

2007

Zheltukhin VF, Metlushka KE, Sadkova DN, McKenna CE, Kashemirov BA, Alfonsov VA. A new approach to the synthesis of benzylidene derivatives of 1-(α-aminobenzyl)-2-naphthols (Betti bases), promising chiral inductors. Mendeleev Communications. 2007;17:239-240.

Zhang H, Marma MS, Kim ES, McKenna CE, Thompson ME. Mercuric Ion Sensing by a Film Bulk Acoustic Resonator. IEEE Trans Ultrason Ferroelectr Freq Control. 2007;54:1723-1725.

Zhang H, Marma MS, Bahl SK, Kim ES, McKenna CE. Sequence Specific Label-Free DNA Sensing Using Film-Bulk-Acoustic-Resonators. IEEE Sens J. 2007;7:1587-1588.

Xia Z, Dunford J, Lawson MA, Triffitt JT, Kavanagh K, Oppermann U, Roze C, Kashemirov B, McKenna CE, Ebetino FH, Russell RG. Predicting pharmacological potencies of nitrogen-containing bisphosphonates; novel methods dissociate enzyme- and hydroxyapatite-binding affinities. Bone. 2007;40:S301-S302.

Sucato C, Upton T, Kashemirov B, Batra V, Martinek V, Xiang Y, Beard W, Pedersen L, Wilson S, McKenna C, Florian J, Warshel A, Goodman M. Modifying the β,γ Leaving-Group Bridging Oxygen Alters Nucleotide Incorporation Efficiency, Fidelity, and the Catalytic Mechanism of DNA Polymerase β. Biochemistry. 2007;46:461-471.

Stewart CA, Dunford JE, Xia Z, Baron R, Marma MS, Kashemirov BA, McKenna CE, Ebetino FH, Coxon FP. Role of the geminal hydroxyl group in target enzyme inhibition by bisphosphonates and phosphonocarboxylates. Calcif Tissue Int. 2007;80:S94-S95.

Stewart CA, Dunford JE, Xia Z, Baron R, Marma MS, Kashemirov BA, McKenna CE, Ebetino FH, Coxon FP. Differential effects of α-halogenation on the potency of bisphosphonates and phosphonocarboxylates for inhibition of their target enzymes. J Bone Miner Res. 2007;22:1130.

Peterson LW, Kashemirov BA, Saejueng K, Breitenbach J, Borysko K, Drach JC, Kim JS, Kijek P, Mitchell S, Hilfinger JM, McKenna CE. Novel Synthetic Approaches to Cidofovir and Foscarnet Prodrugs. Antiviral Res. 2007;74:A74.

Peterson LW, Kashemirov BA, Blazewska KM, Breitenback J, Borysko K, Drach JC, Kim JS, Kijek P, Hilfinger JM, McKenna CE. Synthesis and Structure-Activity Aspects of Some Cyclic Cidofovir Peptidomimetic Prodrugs. Antiviral Res. 2007;74:A33.

McKenna CE, Kashemirov BA, Upton TG, Batra VK, Goodman MF, Pedersen LC, Beard WA, Wilson SH. (R)-β,γ-Fluoromethylene-dGTP-DNA Ternary Complex with DNA Polymerase β. J Am Chem Soc. 2007;129:15412-15413.

Marma MS, Xia Z, Stewart C, Coxon F, Dunford JE, Baron R, Kashemirov BA, Ebetino FH, Triffitt JT, Russell RGG, McKenna CE. Synthesis and Biological Evaluation of α-Halogenated Bisphosphonate and Phosphonocarboxylate Analogues of Risedronate. J Med Chem. 2007;50:5967-5975.

Eriksson U, Hilfinger JM, Kim JS, Mitchell S, Kijek P, Borysko KZ, Breitenbach JM, Drach JC, Kashemirov BA, McKenna CE. Synthesis and biological activation of an ethylene glycol-linked amino acid conjugate of cyclic cidofovir. Bioorg Med Chem Lett. 2007;17:583-586.

Ebetino FH, Dunford JE, Song X, Boeckman RK, Roze C, McKenna CE, Russell RG, Barnetts BL. Stereochemical evidence of the mode of binding of nitrogen containing bisphosphonates in farnesyl diphosphate synthase. Bone. 2007;40:S307-S308.

Alfonsov VA, Metlushka KE, McKenna CE, Kashemirov BA, Kataeva ON, Zheltukhin VF, Sadkova DN, Dobrynin AB. A New Approach to the Enantioseparation of Betti Bases. Synlett. 2007:488-490.